The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.

نویسندگان

  • J A Sandler
  • R I Clyman
  • V C Manganiello
  • M Vaughan
چکیده

The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 55 2  شماره 

صفحات  -

تاریخ انتشار 1975